The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders: Current Progress and Future Challenges
Joint Authors
Wang, Ying
Huang, Haoyue
Li, Jingjing
Shen, Zhenya
Peng, Guang-Yin
Lin, Yang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-12
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Vascular disorders are complex diseases with high morbidity and mortality.
Among them, the dilated macrovascular diseases (MVD), such as aortic aneurysm and aortic dissection, have presented a huge threat to human health.
The pathogenesis of vascular diseases is mostly associated with property alteration of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs).
Studies have confirmed that induced pluripotent stem cells (iPSCs) can be proliferated and differentiated into other somatic cells, such as VECs and VSMCs.
And patient-specific cells could provide detailed human-associated information in regard to pathogenesis or drug responses.
In addition, differentiated ECs from iPSC have been widely used in disease modeling as a cell therapy.
In this review, we mainly discussed the application of hiPSCs in investigating the pathological mechanism of different inherited vascular diseases and provide a comprehensive understanding of hiPSCs in the field of clinical diagnosis and gene therapy.
American Psychological Association (APA)
Peng, Guang-Yin& Lin, Yang& Li, Jingjing& Wang, Ying& Huang, Haoyue& Shen, Zhenya. 2019. The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders: Current Progress and Future Challenges. Stem Cells International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1210032
Modern Language Association (MLA)
Peng, Guang-Yin…[et al.]. The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders: Current Progress and Future Challenges. Stem Cells International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1210032
American Medical Association (AMA)
Peng, Guang-Yin& Lin, Yang& Li, Jingjing& Wang, Ying& Huang, Haoyue& Shen, Zhenya. The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders: Current Progress and Future Challenges. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1210032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210032