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Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics
Joint Authors
Bighetti-Trevisan, Rayana L.
Sousa, Lucas O.
Castilho, Rogerio M.
Almeida, Luciana O.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-12
Country of Publication
Egypt
No. of Pages
15
Abstract EN
A frequent observation in several malignancies is the development of resistance to therapy that results in frequent tumor relapse and metastasis.
Much of the tumor resistance phenotype comes from its heterogeneity that halts the ability of therapeutic agents to eliminate all cancer cells effectively.
Tumor heterogeneity is, in part, controlled by cancer stem cells (CSC).
CSC may be considered the reservoir of cancer cells as they exhibit properties of self-renewal and plasticity and the capability of reestablishing a heterogeneous tumor cell population.
The endowed resistance mechanisms of CSC are mainly attributed to several factors including cellular quiescence, accumulation of ABC transporters, disruption of apoptosis, epigenetic reprogramming, and metabolism.
There is a current need to develop new therapeutic drugs capable of targeting CSC to overcome tumor resistance.
Emerging in vitro and in vivo studies strongly support the potential benefits of combination therapies capable of targeting cancer stem cell-targeting agents.
Clinical trials are still underway to address the pharmacokinetics, safety, and efficacy of combination treatment.
This review will address the main characteristics, therapeutic implications, and perspectives of targeting CSC to improve current anticancer therapeutics.
American Psychological Association (APA)
Bighetti-Trevisan, Rayana L.& Sousa, Lucas O.& Castilho, Rogerio M.& Almeida, Luciana O.. 2019. Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics. Stem Cells International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1210036
Modern Language Association (MLA)
Bighetti-Trevisan, Rayana L.…[et al.]. Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics. Stem Cells International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1210036
American Medical Association (AMA)
Bighetti-Trevisan, Rayana L.& Sousa, Lucas O.& Castilho, Rogerio M.& Almeida, Luciana O.. Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1210036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210036