Laterality of Poststroke Cortical Motor Activity during Action Observation Is Related to Hemispheric Dominance
Joint Authors
Liew, Sook-Lei
Garrison, Kathleen A.
Ito, Kaori L.
Heydari, Panthea
Sobhani, Mona
Werner, Julie
Damasio, Hanna
Winstein, Carolee J.
Aziz-Zadeh, Lisa
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Increased activity in the lesioned hemisphere has been related to improved poststroke motor recovery.
However, the role of the dominant hemisphere—and its relationship to activity in the lesioned hemisphere—has not been widely explored.
Objective.
Here, we examined whether the dominant hemisphere drives the lateralization of brain activity after stroke and whether this changes based on if the lesioned hemisphere is the dominant hemisphere or not.
Methods.
We used fMRI to compare cortical motor activity in the action observation network (AON), motor-related regions that are active both during the observation and execution of an action, in 36 left hemisphere dominant individuals.
Twelve individuals had nondominant, right hemisphere stroke, twelve had dominant, left-hemisphere stroke, and twelve were healthy age-matched controls.
We previously found that individuals with left dominant stroke show greater ipsilesional activity during action observation.
Here, we examined if individuals with nondominant, right hemisphere stroke also showed greater lateralized activity in the ipsilesional, right hemisphere or in the dominant, left hemisphere and compared these results with those of individuals with dominant, left hemisphere stroke.
Results.
We found that individuals with right hemisphere stroke showed greater activity in the dominant, left hemisphere, rather than the ipsilesional, right hemisphere.
This left-lateralized pattern matched that of individuals with left, dominant hemisphere stroke, and both stroke groups differed from the age-matched control group.
Conclusions.
These findings suggest that action observation is lateralized to the dominant, rather than ipsilesional, hemisphere, which may reflect an interaction between the lesioned hemisphere and the dominant hemisphere in driving lateralization of brain activity after stroke.
Hemispheric dominance and laterality should be carefully considered when characterizing poststroke neural activity.
American Psychological Association (APA)
Liew, Sook-Lei& Garrison, Kathleen A.& Ito, Kaori L.& Heydari, Panthea& Sobhani, Mona& Werner, Julie…[et al.]. 2018. Laterality of Poststroke Cortical Motor Activity during Action Observation Is Related to Hemispheric Dominance. Neural Plasticity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210040
Modern Language Association (MLA)
Liew, Sook-Lei…[et al.]. Laterality of Poststroke Cortical Motor Activity during Action Observation Is Related to Hemispheric Dominance. Neural Plasticity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1210040
American Medical Association (AMA)
Liew, Sook-Lei& Garrison, Kathleen A.& Ito, Kaori L.& Heydari, Panthea& Sobhani, Mona& Werner, Julie…[et al.]. Laterality of Poststroke Cortical Motor Activity during Action Observation Is Related to Hemispheric Dominance. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210040