Role of Adiponectin in Central Nervous System Disorders
Joint Authors
Judd, Robert L.
Bloemer, Jenna
Pinky, Priyanka D.
Govindarajulu, Manoj
Hong, Hao
Amin, Rajesh H.
Moore, Timothy
Dhanasekaran, Muralikrishnan
Reed, Miranda N.
Suppiramaniam, Vishnu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Adiponectin, the most abundant plasma adipokine, plays an important role in the regulation of glucose and lipid metabolism.
Adiponectin also possesses insulin-sensitizing, anti-inflammatory, angiogenic, and vasodilatory properties which may influence central nervous system (CNS) disorders.
Although initially not thought to cross the blood-brain barrier, adiponectin enters the brain through peripheral circulation.
In the brain, adiponectin signaling through its receptors, AdipoR1 and AdipoR2, directly influences important brain functions such as energy homeostasis, hippocampal neurogenesis, and synaptic plasticity.
Overall, based on its central and peripheral actions, recent evidence indicates that adiponectin has neuroprotective, antiatherogenic, and antidepressant effects.
However, these findings are not without controversy as human observational studies report differing correlations between plasma adiponectin levels and incidence of CNS disorders.
Despite these controversies, adiponectin is gaining attention as a potential therapeutic target for diverse CNS disorders, such as stroke, Alzheimer’s disease, anxiety, and depression.
Evidence regarding the emerging role for adiponectin in these disorders is discussed in the current review.
American Psychological Association (APA)
Bloemer, Jenna& Pinky, Priyanka D.& Govindarajulu, Manoj& Hong, Hao& Judd, Robert L.& Amin, Rajesh H.…[et al.]. 2018. Role of Adiponectin in Central Nervous System Disorders. Neural Plasticity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210099
Modern Language Association (MLA)
Bloemer, Jenna…[et al.]. Role of Adiponectin in Central Nervous System Disorders. Neural Plasticity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210099
American Medical Association (AMA)
Bloemer, Jenna& Pinky, Priyanka D.& Govindarajulu, Manoj& Hong, Hao& Judd, Robert L.& Amin, Rajesh H.…[et al.]. Role of Adiponectin in Central Nervous System Disorders. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210099