Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection
Joint Authors
Bakos, Jan
Bacova, Zuzana
Srancikova, Annamaria
Havranek, Tomas
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aberrant regulation of oxytocin signaling is associated with the etiology of neurodevelopmental disorders.
Synaptic dysfunctions in neurodevelopmental disorders are becoming increasingly known, and their pathogenic mechanisms could be a target of potential therapeutic intervention.
Therefore, it is important to pay attention to the role of oxytocin and its receptor in synapse structure, function, and neuron connectivity.
An early alteration in oxytocin signaling may disturb neuronal maturation and may have short-term and long-term pathological consequences.
At the molecular level, neurodevelopmental disorders include alterations in cytoskeletal rearrangement and neuritogenesis resulting in a diversity of synaptopathies.
The presence of oxytocin receptors in the presynaptic and postsynaptic membranes and the direct effects of oxytocin on neuronal excitability by regulating the activity of ion channels in the cell membrane implicate that alterations in oxytocin signaling could be involved in synaptopathies.
The ability of oxytocin to modulate neurogenesis, synaptic plasticity, and certain parameters of cytoskeletal arrangement is discussed in the present review.
American Psychological Association (APA)
Bakos, Jan& Srancikova, Annamaria& Havranek, Tomas& Bacova, Zuzana. 2018. Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection. Neural Plasticity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210117
Modern Language Association (MLA)
Bakos, Jan…[et al.]. Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection. Neural Plasticity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210117
American Medical Association (AMA)
Bakos, Jan& Srancikova, Annamaria& Havranek, Tomas& Bacova, Zuzana. Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210117