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NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition
Joint Authors
Baez, María Verónica
Cercato, Magalí Cecilia
Jerusalinsky, Diana Alicia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
NMDA ionotropic glutamate receptors (NMDARs) are crucial in activity-dependent synaptic changes and in learning and memory.
NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their pharmacological and physiological profile.
In CNS structures involved in cognitive functions as the hippocampus and prefrontal cortex, GluN2A and GluN2B are major regulatory subunits; their expression is dynamic and tightly regulated, but little is known about specific changes after plasticity induction or memory acquisition.
Data strongly suggest that following appropriate stimulation, there is a rapid increase in surface GluN2A-NMDAR at the postsynapses, attributed to lateral receptor mobilization from adjacent locations.
Whenever synaptic plasticity is induced or memory is consolidated, more GluN2A-NMDARs are assembled likely using GluN2A from a local translation and GluN1 from local ER.
Later on, NMDARs are mobilized from other pools, and there are de novo syntheses at the neuron soma.
Changes in GluN1 or NMDAR levels induced by synaptic plasticity and by spatial memory formation seem to occur in different waves of NMDAR transport/expression/degradation, with a net increase at the postsynaptic side and a rise in expression at both the spine and neuronal soma.
This review aims to put together that information and the proposed hypotheses.
American Psychological Association (APA)
Baez, María Verónica& Cercato, Magalí Cecilia& Jerusalinsky, Diana Alicia. 2018. NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition. Neural Plasticity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210131
Modern Language Association (MLA)
Baez, María Verónica…[et al.]. NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition. Neural Plasticity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1210131
American Medical Association (AMA)
Baez, María Verónica& Cercato, Magalí Cecilia& Jerusalinsky, Diana Alicia. NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210131