Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences
Joint Authors
Ortiz-Guerrero, Gloria
Amador-Muñoz, Diana
Calderón-Ospina, Carlos Alberto
López-Fuentes, Daniel
Nava Mesa, Mauricio Orlando
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common type of dementia, mainly encompassing cognitive decline in subjects aged ≥65 years.
Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (Aβ) and neurofibrillary tangles formed by hyperphosphorylated tau protein.
Dementia and AD are chronic neurodegenerative conditions with a complex physiopathology involving both genetic and environmental factors.
Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD.
However, a recent case-control study reported decreased risk of dementia.
PPIs are a widely indicated class of drugs for gastric acid-related disorders, although most older adult users are not treated for the correct indication.
Although neurological side effects secondary to PPIs are rare, several preclinical reports indicate that PPIs might increase Aβ levels, interact with tau protein, and affect the neuronal microenvironment through several mechanisms.
Considering the controversy between PPI use and dementia risk, as well as both cognitive and neuroprotective effects, the aim of this review is to examine the relationship between PPI use and brain effects from a neurobiological and clinical perspective.
American Psychological Association (APA)
Ortiz-Guerrero, Gloria& Amador-Muñoz, Diana& Calderón-Ospina, Carlos Alberto& López-Fuentes, Daniel& Nava Mesa, Mauricio Orlando. 2018. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plasticity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210140
Modern Language Association (MLA)
Ortiz-Guerrero, Gloria…[et al.]. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plasticity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210140
American Medical Association (AMA)
Ortiz-Guerrero, Gloria& Amador-Muñoz, Diana& Calderón-Ospina, Carlos Alberto& López-Fuentes, Daniel& Nava Mesa, Mauricio Orlando. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210140