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Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex Vivo 1H Nuclear Magnetic Resonance Spectroscopy in the Prefrontal Cortex, Hippocampus, and Hypothalamus
Joint Authors
Yan, Zhihan
Bai, Guanghui
Ye, Xinjian
He, Jiawei
Liu, Kun
Zhao, Liangcai
Xu, Wen
Lin, Qiuting
Zhou, Yongjin
Huang, Xiaoyan
Gao, Hong-Chang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic patients often present with comorbid depression.
However, the pathogenetic mechanisms underlying diabetic depression (DD) remain unclear.
To explore the mechanisms underpinning the pathogenesis of the disease, we used ex vivo 1H nuclear magnetic resonance spectroscopy and immunohistochemistry to investigate the main metabolic and pathological changes in various rat brain areas in an animal model of DD.
Compared with the control group, rats in the DD group showed significant decreases in neurotransmitter concentrations of glutamate (Glu) and glutamine (Gln) in the prefrontal cortex (PFC), hippocampus, and hypothalamus and aspartate and glycine in the PFC and hypothalamus.
Gamma-aminobutyric acid (GABA) was decreased only in the hypothalamus.
Levels of the energy product, lactate, were higher in the PFC, hippocampus, and hypothalamus of rats with DD than those in control rats, while creatine was lower in the PFC and hippocampus, and alanine was lower in the hypothalamus.
The levels of other brain metabolites were altered, including N-acetyl aspartate, taurine, and choline.
Immunohistochemistry analysis revealed that expressions of both glutamine synthetase and glutaminase were decreased in the PFC, hippocampus, and hypothalamus of rats with DD.
The metabolic changes in levels of Glu, Gln, and GABA indicate an imbalance of the Glu-Gln metabolic cycle between astrocytes and neurons.
Our results suggest that the development of DD in rats may be linked to brain metabolic changes, including inhibition of the Glu-Gln cycle, increases in anaerobic glycolysis, and disturbances in the lactate-alanine shuttle, and associated with dysfunction of neurons and astrocytes.
American Psychological Association (APA)
Liu, Kun& Zhao, Liangcai& Xu, Wen& Lin, Qiuting& Zhou, Yongjin& Huang, Xiaoyan…[et al.]. 2018. Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex Vivo 1H Nuclear Magnetic Resonance Spectroscopy in the Prefrontal Cortex, Hippocampus, and Hypothalamus. Neural Plasticity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210274
Modern Language Association (MLA)
Liu, Kun…[et al.]. Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex Vivo 1H Nuclear Magnetic Resonance Spectroscopy in the Prefrontal Cortex, Hippocampus, and Hypothalamus. Neural Plasticity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210274
American Medical Association (AMA)
Liu, Kun& Zhao, Liangcai& Xu, Wen& Lin, Qiuting& Zhou, Yongjin& Huang, Xiaoyan…[et al.]. Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex Vivo 1H Nuclear Magnetic Resonance Spectroscopy in the Prefrontal Cortex, Hippocampus, and Hypothalamus. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210274