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Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives
Joint Authors
Cordova, C.
Marchant, I.
Olivero, P.
Sotomayor-Zárate, Ramón
Ramírez-Barrantes, Ricardo
Arancibia, Marcelo
Lozano, Carlo
Meza-Concha, Nicolás
González-Arriagada, Wilfredo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Proteostasis involves processes that are fundamental for neural viability.
Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with several neuropsychiatric conditions.
It has been observed that impaired mitochondrial function due to a dysregulated proteostasis control system, that is, ubiquitin-proteasome system and chaperones, could also have effects on neurodegenerative disorders.
We aimed to critically analyze the available findings regarding the neurobiological implications of proteostasis on the development of neurodegenerative and psychiatric diseases, considering the mitochondrial role.
Proteostasis alterations in the prefrontal cortex implicate proteome instability and accumulation of misfolded proteins.
Altered mitochondrial dynamics, especially in proteostasis processes, could impede the normal compensatory mechanisms against cell damage.
Thereby, altered mitochondrial functions on regulatory modulation of dendritic development, neuroinflammation, and respiratory function may underlie the development of some psychiatric conditions, such as schizophrenia, being influenced by a genetic background.
It is expected that with the increasing evidence about proteostasis in neuropsychiatric disorders, new therapeutic alternatives will emerge.
American Psychological Association (APA)
Olivero, P.& Lozano, Carlo& Sotomayor-Zárate, Ramón& Meza-Concha, Nicolás& Arancibia, Marcelo& Cordova, C.…[et al.]. 2018. Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210287
Modern Language Association (MLA)
Olivero, P.…[et al.]. Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210287
American Medical Association (AMA)
Olivero, P.& Lozano, Carlo& Sotomayor-Zárate, Ramón& Meza-Concha, Nicolás& Arancibia, Marcelo& Cordova, C.…[et al.]. Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210287