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Anticorrelations between Active Brain Regions: An Agent-Based Model Simulation Study
Joint Authors
Colosimo, Alfredo
Parente, Fabrizio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Anticorrelations among brain areas observed in fMRI acquisitions under resting state are not endowed with a well-defined set of characters.
Some evidence points to a possible physiological role for them, and simulation models showed that it is appropriate to explore such an issue.
A large-scale brain representation was considered, implementing an agent-based brain-inspired model (ABBM) incorporating the SER (susceptible-excited-refractory) cyclic mechanism of state change.
The experimental data used for validation included 30 selected functional images of healthy controls from the 1000 Functional Connectomes Classic collection.
To study how different fractions of positive and negative connectivities could modulate the model efficiency, the correlation coefficient was systematically used to check the goodness-of-fit of empirical data by simulations under different combinations of parameters.
The results show that a small fraction of positive connectivity is necessary to match at best the empirical data.
Similarly, a goodness-of-fit improvement was observed upon addition of negative links to an initial pattern of only-positive connections, indicating a significant information intrinsic to negative links.
As a general conclusion, anticorrelations showed that it is crucial to improve the performance of our simulation and, since these cannot be assimilated to noise, should be always considered in order to refine any brain functional model.
American Psychological Association (APA)
Parente, Fabrizio& Colosimo, Alfredo. 2018. Anticorrelations between Active Brain Regions: An Agent-Based Model Simulation Study. Neural Plasticity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210289
Modern Language Association (MLA)
Parente, Fabrizio& Colosimo, Alfredo. Anticorrelations between Active Brain Regions: An Agent-Based Model Simulation Study. Neural Plasticity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1210289
American Medical Association (AMA)
Parente, Fabrizio& Colosimo, Alfredo. Anticorrelations between Active Brain Regions: An Agent-Based Model Simulation Study. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210289