Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms

Joint Authors

Snider, Kaitlin H.
Sullivan, Kyle A.
Obrietan, Karl

Source

Neural Plasticity

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-02-08

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Biology
Medicine

Abstract EN

Circadian modulation of learning and memory efficiency is an evolutionarily conserved phenomenon, occurring in organisms ranging from invertebrates to higher mammalian species, including humans.

While the suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master mammalian pacemaker, recent evidence suggests that forebrain regions, including the hippocampus, exhibit oscillatory capacity.

This finding, as well as work on the cellular signaling events that underlie learning and memory, has opened promising new avenues of investigation into the precise cellular, molecular, and circuit-based mechanisms by which clock timing impacts plasticity and cognition.

In this review, we examine the complex molecular relationship between clock timing and memory, with a focus on hippocampal-dependent tasks.

We evaluate how the dysregulation of circadian timing, both at the level of the SCN and at the level of ancillary forebrain clocks, affects learning and memory.

Further, we discuss experimentally validated intracellular signaling pathways (e.g., ERK/MAPK and GSK3β) and potential cellular signaling mechanisms by which the clock affects learning and memory formation.

Finally, we examine how long-term potentiation (LTP), a synaptic process critical to the establishment of several forms of memory, is regulated by clock-gated processes.

American Psychological Association (APA)

Snider, Kaitlin H.& Sullivan, Kyle A.& Obrietan, Karl. 2018. Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms. Neural Plasticity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210335

Modern Language Association (MLA)

Snider, Kaitlin H.…[et al.]. Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms. Neural Plasticity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1210335

American Medical Association (AMA)

Snider, Kaitlin H.& Sullivan, Kyle A.& Obrietan, Karl. Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210335

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1210335