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Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study
Joint Authors
Dong, Li
Luo, Cheng
Peng, Rui
Zhong, Chengqing
Liu, Rong
Jiang, Sisi
Guo, Fuqiang
Wang, Pu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI).
High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects.
A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV).
Then, the observed structural and FCs were associated with the clinical manifestations.
The decreased GMV regions were found in the bilateral anterior cerebellum, the right orbital superior frontal gyrus, the left middle temporal gyrus, the left putamen, the right hippocampus, the bilateral caudate, and the right thalamus.
The changed FCs were mainly observed in the motor-related areas and the cognitive-related areas.
The significant findings of this study revealed an important role for the cerebellum in motor control and cognitive regulation in JME patients, which also have an effect on the activity of the occipital lobe.
In addition, the changed FCs were related to the clinical features of JME patients.
The current observations may contribute to the understanding of the pathogenesis of JME.
American Psychological Association (APA)
Zhong, Chengqing& Liu, Rong& Luo, Cheng& Jiang, Sisi& Dong, Li& Peng, Rui…[et al.]. 2018. Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study. Neural Plasticity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210347
Modern Language Association (MLA)
Zhong, Chengqing…[et al.]. Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study. Neural Plasticity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210347
American Medical Association (AMA)
Zhong, Chengqing& Liu, Rong& Luo, Cheng& Jiang, Sisi& Dong, Li& Peng, Rui…[et al.]. Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210347