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Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome
Joint Authors
Zhao, Huan
Yang, Tao
Gao, Fei
Qi, Lijun
Yang, Zhongzhen
Zhang, Yan
Xu, Hui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by silence of the fmr1 gene and the deficiency of Fragile X mental retardation protein (FMRP).
Patients present neuronal alterations that lead to severe intellectual disability and altered sleep rhythms.
However, the neural circuit mechanisms underlying FXS remain unclear.
Previous studies have suggested that metabolic glutamate and gamma-aminobutyric acid (GABA) receptors/circuits are two counter-balanced factors involved in FXS pathophysiology.
More and more studies demonstrated that attenuated GABAergic circuits in the absence of FMRP are critical for abnormal progression of FXS.
Here, we reviewed the changes of GABA neural circuits that were attributed to intellectual-deficient FXS, from several aspects including deregulated GABA metabolism, decreased expressions of GABA receptor subunits, and impaired GABAergic neural circuits.
Furthermore, the activities of GABA neural circuits are modulated by circadian rhythm of FMRP metabolism and reviewed the abnormal condition of FXS mice or patients.
American Psychological Association (APA)
Gao, Fei& Qi, Lijun& Yang, Zhongzhen& Yang, Tao& Zhang, Yan& Xu, Hui…[et al.]. 2018. Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome. Neural Plasticity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1210464
Modern Language Association (MLA)
Gao, Fei…[et al.]. Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome. Neural Plasticity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1210464
American Medical Association (AMA)
Gao, Fei& Qi, Lijun& Yang, Zhongzhen& Yang, Tao& Zhang, Yan& Xu, Hui…[et al.]. Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1210464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210464