Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration
Joint Authors
Qian, Changhui
Tan, Dandan
Wang, Xianghai
Li, Lixia
Wen, Jinkun
Pan, Mengjie
Li, Yuanyuan
Guo, Jiasong
Wu, Wutian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Accumulating evidences suggest that peripheral nerve injury (PNI) may initiate astrocytic responses in the central nervous system (CNS).
However, the response of astrocytes in the spinal ventral horn and its potential role in nerve regeneration after PNI remain unclear.
Herein, we firstly illustrated that astrocytes in the spinal ventral horn were dramatically activated in the early stage following sciatic nerve injury, and these profiles were eliminated in the chronic stage.
Additionally, we found that the expression of neurotrophins, including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3), also accompanied with astrocyte activation.
In comparison with the irreversible transected subjects, astrocyte activation and the neurotrophic upregulation in the early stage were more drastic in case the transected nerve was rebridged immediately after injury.
Furthermore, administering fluorocitrate to inhibit astrocyte activation resulted in decreased neurotrophin expression in the spinal ventral horn and delayed axonal regeneration in the nerve as well as motor function recovery.
Overall, the present study indicates that peripheral nerve injury can initiate astrocyte activation accompanied with neurotrophin upregulation in the spinal ventral horn.
The above responses mainly occur in the early stage of PNI and may contribute to nerve regeneration and motor function recovery.
American Psychological Association (APA)
Qian, Changhui& Tan, Dandan& Wang, Xianghai& Li, Lixia& Wen, Jinkun& Pan, Mengjie…[et al.]. 2018. Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration. Neural Plasticity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210484
Modern Language Association (MLA)
Qian, Changhui…[et al.]. Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration. Neural Plasticity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210484
American Medical Association (AMA)
Qian, Changhui& Tan, Dandan& Wang, Xianghai& Li, Lixia& Wen, Jinkun& Pan, Mengjie…[et al.]. Peripheral Nerve Injury-Induced Astrocyte Activation in Spinal Ventral Horn Contributes to Nerve Regeneration. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210484