CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons
Joint Authors
Liu, Zhi-Zhi
Zhu, Jian
Wang, Chang-Ling
Wang, Xin
Han, Ying-Ying
Liu, Ling-Yan
Xu, Hong A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Axons are directed to their correct targets by guidance cues during neurodevelopment.
Many axon guidance cues have been discovered; however, much less known is about how the growth cones transduce the extracellular guidance cues to intracellular responses.
Collapsin response mediator proteins (CRMPs) are a family of intracellular proteins that have been found to mediate growth cone behavior in vitro; however, their roles in vivo in axon development are much less explored.
In zebrafish embryos, we find that CRMP2 and CRMP4 are expressed in the retinal ganglion cell layer when retinal axons are crossing the midline.
Knocking down CRMP2 causes reduced elongation and premature termination of the retinal axons, while knocking down CRMP4 results in ipsilateral misprojections of retinal axons that would normally project to the contralateral brain.
Furthermore, CRMP4 synchronizes with neuropilin 1 in retinal axon guidance, suggesting that CRMP4 might mediate the semaphorin/neuropilin signaling pathway.
These results demonstrate that CRMP2 and CRMP4 function differentially in axon development in vivo.
American Psychological Association (APA)
Liu, Zhi-Zhi& Zhu, Jian& Wang, Chang-Ling& Wang, Xin& Han, Ying-Ying& Liu, Ling-Yan…[et al.]. 2018. CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210497
Modern Language Association (MLA)
Liu, Zhi-Zhi…[et al.]. CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210497
American Medical Association (AMA)
Liu, Zhi-Zhi& Zhu, Jian& Wang, Chang-Ling& Wang, Xin& Han, Ying-Ying& Liu, Ling-Yan…[et al.]. CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210497