Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice
Joint Authors
Xu, Shi-Yuan
Tao, Tao
Lai, Lu-Ying
Hong, Pu
Li, Feng-Xian
Gu, Ruo-Nan
Fang, Ying-Ying
Wang, Yong-Wei
You, Zhi-Jian
Zhang, Hong-Fei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke.
However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes.
We aim to investigate the effect and the potential mechanism of NLRP3 inflammasome in diabetic mice with cerebral ischemia-reperfusion injury.
A type 2 diabetic mouse model was induced by a high-fat diet and streptozotocin (STZ).
Diabetic mice received MCC950 (the specific molecule NLRP3 inhibitor) or vehicle 60 minutes before the middle cerebral artery occlusion (MCAO) and reperfusion.
MCC950 reduced the neurological deficit score of 24 h after cerebral ischemia reperfusion and improved the 28-day survival rate of cerebral ischemia-reperfusion injury in diabetic mice.
Furthermore, we found that the mRNA transcription levels of NLRP3, IL-1β, and caspase-1 in the core ischemic area were remarkably amplified in diabetic mice with cerebral ischemia-reperfusion injury, whereas this phenomenon was obviously attenuated by MCC950 pretreatment.
In conclusion, the NLRP3 inflammasome was involved in the complex diseases of diabetic stroke.
MCC950, the NLRP3 specific inhibitor, ameliorated diabetic mice with cerebral ischemia-reperfusion injury and improved the 28-day survival rate during the recovery stage of ischemic stroke.
American Psychological Association (APA)
Hong, Pu& Li, Feng-Xian& Gu, Ruo-Nan& Fang, Ying-Ying& Lai, Lu-Ying& Wang, Yong-Wei…[et al.]. 2018. Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plasticity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210505
Modern Language Association (MLA)
Hong, Pu…[et al.]. Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plasticity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210505
American Medical Association (AMA)
Hong, Pu& Li, Feng-Xian& Gu, Ruo-Nan& Fang, Ying-Ying& Lai, Lu-Ying& Wang, Yong-Wei…[et al.]. Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210505