Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission
Joint Authors
Hou, Gonglin
Yuan, Ti-Fei
Lin, Min
Zhao, Ying
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic stress results in neurochemical, physiological, immune, molecular, cellular, and structural changes in the brain and often dampens the cognition.
The hippocampus has been one major focus in studying the stress responsivity and neural mechanisms underlying depression.
Both acute and chronic stress stimuli lead to dynamic changes in excitatory transmission in the hippocampus.
The present study examined the potential effects of spontaneous recovery after chronic stress on spatial memory function and glutamatergic transmission in the hippocampus.
The results showed that chronic unpredicted mild stress transiently increased AMPA receptor GluA2/3 subunit expression, together with elevated PICK-1 protein expression.
Spontaneous recovery restored the behavioral deficits in Barnes maze test, as well as the glutamate receptor expression changes.
In conclusion, spontaneous recovery acts as an important mechanism in system homeostasis.
American Psychological Association (APA)
Lin, Min& Hou, Gonglin& Zhao, Ying& Yuan, Ti-Fei. 2018. Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission. Neural Plasticity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210537
Modern Language Association (MLA)
Lin, Min…[et al.]. Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission. Neural Plasticity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1210537
American Medical Association (AMA)
Lin, Min& Hou, Gonglin& Zhao, Ying& Yuan, Ti-Fei. Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210537