Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex
Joint Authors
Sun, Jing-wu
Huang, Yina
Liu, Congli
Xu, Tao
Liu, Xiaopeng
Wang, Haitao
Luo, Bin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acoustic trauma is being reported to damage the auditory periphery and central system, and the compromised cortical inhibition is involved in auditory disorders, such as hyperacusis and tinnitus.
Parvalbumin-containing neurons (PV neurons), a subset of GABAergic neurons, greatly shape and synchronize neural network activities.
However, the change of PV neurons following acoustic trauma remains to be elucidated.
The present study investigated how auditory cortical PV neurons change following unilateral 1 hour noise exposure (left ear, one octave band noise centered at 16 kHz, 116 dB SPL).
Noise exposure elevated the auditory brainstem response threshold of the exposed ear when examined 7 days later.
More detectable PV neurons were observed in both sides of the auditory cortex of noise-exposed rats when compared to control.
The detectable PV neurons of the left auditory cortex (ipsilateral to the exposed ear) to noise exposure outnumbered those of the right auditory cortex (contralateral to the exposed ear).
Quantification of Western blotted bands revealed higher expression level of PV protein in the left cortex.
These findings of more active PV neurons in noise-exposed rats suggested that a compensatory mechanism might be initiated to maintain a stable state of the brain.
American Psychological Association (APA)
Liu, Congli& Xu, Tao& Liu, Xiaopeng& Huang, Yina& Wang, Haitao& Luo, Bin…[et al.]. 2018. Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex. Neural Plasticity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1210564
Modern Language Association (MLA)
Liu, Congli…[et al.]. Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex. Neural Plasticity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1210564
American Medical Association (AMA)
Liu, Congli& Xu, Tao& Liu, Xiaopeng& Huang, Yina& Wang, Haitao& Luo, Bin…[et al.]. Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1210564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210564