Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity
Joint Authors
Quinlan, Erin Burke
Dodakian, Lucy
See, Jill
McKenzie, Alison
Stewart, Jill Campbell
Cramer, Steven C.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Biomarkers that capture treatment effects could improve the precision of clinical decision making for restorative therapies.
We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18 patients with chronic stroke and hypothesized that results vary significantly according to stroke severity.
Patients were 4.1 ± 1 months poststroke, with baseline arm Fugl-Meyer scores of 20–60.
When all patients were examined together, no imaging measure changed over time in a manner that correlated with treatment-induced motor gains.
However, when also considering the interaction with baseline motor status, treatment-induced motor gains were significantly related to change in three functional connectivity measures: ipsilesional motor cortex connectivity with (1) contralesional motor cortex (p=0.003), (2) contralesional dorsal premotor cortex (p=0.005), and (3) ipsilesional dorsal premotor cortex (p=0.004).
In more impaired patients, larger treatment gains were associated with greater increases in functional connectivity, whereas in less impaired patients larger treatment gains were associated with greater decreases in functional connectivity.
Functional connectivity measures performed best as biomarkers of treatment effects after stroke.
The relationship between changes in functional connectivity and treatment gains varied according to baseline stroke severity.
Biomarkers of restorative therapy effects are not one-size-fits-all after stroke.
American Psychological Association (APA)
Quinlan, Erin Burke& Dodakian, Lucy& See, Jill& McKenzie, Alison& Stewart, Jill Campbell& Cramer, Steven C.. 2018. Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity. Neural Plasticity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210567
Modern Language Association (MLA)
Quinlan, Erin Burke…[et al.]. Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity. Neural Plasticity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210567
American Medical Association (AMA)
Quinlan, Erin Burke& Dodakian, Lucy& See, Jill& McKenzie, Alison& Stewart, Jill Campbell& Cramer, Steven C.. Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210567