The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS
Joint Authors
De Carvalho, Mamede
Braga, Anna Caroline Marques
Pinto, Anabela
Pinto, Susana
Source
Neurology Research International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS).
We studied this intervention.
Methods.
We included 48 ALS patients randomized in 2 groups: G1 (n=24), exercise intensity leveled by CPET; G2 (n=24), standard care limited by fatigue, during 6 months.
ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission (T1) and 6 months later (T2).
We registered oxygen uptake, carbon dioxide output, and ventilation at anaerobic threshold and at peak effort.
Primary outcome was functional change.
We used parametric statistics for comparisons and multiple regression analyses to identify independent predictors of functional decline.
Results.
At T1 both groups were identical, except for higher FVC in G1 (p=0.02).
At T2, ALSFRS-R was higher (p=0.035) in G1.
Gas exchange variables at T2 did not change in G1 but had significant differences in G2 (p<0.05).
Multiregression analyses showed the Spinal ALSFRS-R slope and Intervention group (p<0.001) as significant predictors of ALSFRS-R at T2.
Conclusion.
Aerobic exercise defined by CPET is feasible and can improve functional outcome in ALS.
This trial is registered with Clinical trials.gov ID: NCT03326622.
American Psychological Association (APA)
Braga, Anna Caroline Marques& Pinto, Anabela& Pinto, Susana& De Carvalho, Mamede. 2018. The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS. Neurology Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210617
Modern Language Association (MLA)
Braga, Anna Caroline Marques…[et al.]. The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS. Neurology Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210617
American Medical Association (AMA)
Braga, Anna Caroline Marques& Pinto, Anabela& Pinto, Susana& De Carvalho, Mamede. The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS. Neurology Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210617