Placental Peripartum Pathologies in Women with Preeclampsia and Eclampsia
Joint Authors
Eleje, George Uchenna
Okafor, Charles Ikechukwu
Ezeigwe, Chijioke Ogomegbulam
Udigwe, Gerald Okanandu
Anyiam, Daniel Chukwuemeka
Source
Obstetrics and Gynecology International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine the pattern of pathological changes in placentas of preeclamptic/eclamptic parturients and its correlation with the clinical severity as well as the perinatal outcome.
Methods.
A cross-sectional analytical study of placental pathologies in preeclamptic/eclamptic patients was performed in a blinded pattern and compared with matched normal controls.
Data were analyzed using Epi-Info 2008 version 3.5.1.
Results.
Placental pathologies were evaluated in 61 preeclamptic/eclamptic patients and in 122 controls.
Of the 61 placentas, 53 (4.7%) were of preeclampsia while 8 (0.71%) were of eclampsia.
Of the preeclamptic group, 14 (23%) had mild preeclampsia while 39 (63.9%) had severe preeclampsia.
Infarction, haematoma, and some histological changes increased with the severity of preeclampsia (p<0.001).
When comparing placentas in eclampsia, severe preeclampsia, mild preeclampsia, and normal controls, there was respective increase in the presence of any infarction (75%, 66.7%, 35.7% vs.
12.3%) or any haematoma (100%, 100%, 71.4% vs.
35.2%), decidual arteriopathy (87.5%, 76.9%, 64.3% vs.
35.2%), cytotrophoblastic proliferation (75%, 71.8%, 42.9% vs.
25.4%), and accelerated villous maturation (75%, 69.2%, 57.1% vs.
31.1%).
There was no statistically significant difference in placental calcifications, stromal oedema, stromal fibrosis, and syncytial knots.
Degree of placental infarction was correlated with the fetal birth weight.
The fetal birth weight with placental involvement of >10% was significant (p=0.01).
Conclusion.
In mild or severe preeclampsia/eclampsia, placentas had significant histological signs of ischaemia and degree of placental involvement by infarction is inversely proportional to fetal birth weight.
While feto-placental ratio was higher with increased severity of the disease, the mean weight was less.
This trial is registered with researchregistry3503.
American Psychological Association (APA)
Ezeigwe, Chijioke Ogomegbulam& Okafor, Charles Ikechukwu& Eleje, George Uchenna& Udigwe, Gerald Okanandu& Anyiam, Daniel Chukwuemeka. 2018. Placental Peripartum Pathologies in Women with Preeclampsia and Eclampsia. Obstetrics and Gynecology International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210713
Modern Language Association (MLA)
Ezeigwe, Chijioke Ogomegbulam…[et al.]. Placental Peripartum Pathologies in Women with Preeclampsia and Eclampsia. Obstetrics and Gynecology International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210713
American Medical Association (AMA)
Ezeigwe, Chijioke Ogomegbulam& Okafor, Charles Ikechukwu& Eleje, George Uchenna& Udigwe, Gerald Okanandu& Anyiam, Daniel Chukwuemeka. Placental Peripartum Pathologies in Women with Preeclampsia and Eclampsia. Obstetrics and Gynecology International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210713