Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause
Joint Authors
Wattanathorn, Jintanaporn
Wannanon, Panakaporn
Thipkaew, Chonlathip
Tong-Un, Terdthai
Muchimapura, Supaporn
Thukham-mee, Wipawee
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We aimed to determine the protective effects against cerebral ischemia and osteoporosis of Morinda citrifolia extract in experimental menopause.
The neuroprotective effect was assessed by giving M.
citrifolia leaf extract at doses of 2, 10, and 50 mg/kg BW to the bilateral ovariectomized (OVX) rats for 7 days.
Then, they were occluded in the right middle cerebral artery (MCAO) for 90 minutes.
The neurological score, brain infarction volume, oxidative stress status, and ERK1/2 and eNOS activities were assessed 24 hours later.
M.
citrifolia improved neurological score, brain infarction, and brain oxidative stress status in the cortex of OVX rats plus the MCAO.
No changes in ERK 1/2 signal pathway and NOS expression were observed in this area.
Our data suggested that the neuroprotective effect of the extract might occur partly via the improvement of oxidative stress status in the cortex.
The antiosteoporotic effect in OVX rats was also assessed after an 84-day intervention of M.
citrifolia.
The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats which received the extract.
Therefore, the current data suggested that the extract possessed antiosteoporotic effect by increasing bone formation but decreasing bone resorption.
American Psychological Association (APA)
Wattanathorn, Jintanaporn& Thipkaew, Chonlathip& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai. 2018. Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210804
Modern Language Association (MLA)
Wattanathorn, Jintanaporn…[et al.]. Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1210804
American Medical Association (AMA)
Wattanathorn, Jintanaporn& Thipkaew, Chonlathip& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai. Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210804