Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo
Joint Authors
Shukla, Kirtikar
Sonowal, Himangshu
Kota, Sumedha
Saxena, Ashish
Ramana, Kota V.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Increased side toxicities and development of drug resistance are the major concern for the cancer chemotherapy using synthetic drugs.
Therefore, identification of novel natural antioxidants with potential therapeutic efficacies is important.
In the present study, we have examined how the antioxidant and anti-inflammatory activities of vialinin A, a p-terphenyl compound derived from Chinese edible mushroom T.
terrestris and T.
vialis, prevents human umbilical vascular endothelial cell (HUVEC) neovascularization in vitro and in vivo models.
Pretreatment of HUVECs with vialinin A prevents vascular endothelial growth factor- (VEGF) induced HUVEC cell growth in a dose-dependent manner.
Further, vialinin A also inhibits VEGF-induced migration as well as tube formation of HUVECs.
Treatment of HUVECs prevents VEGF-induced generation of reactive oxygen species (ROS) and malondialdehyde (MDA) and also inhibits VEGF-induced NF-κB nuclear translocation as well as DNA-binding activity.
The VEGF-induced release of various angiogenic cytokines and chemokines in HUVECs was also significantly blunted by vialinin A.
Most importantly, in a mouse model of Matrigel plug assay, vialinin A prevents the formation of new blood vessels and the expression of CD31 and vWF.
Thus, our results indicate a novel role of vialinin A in the prevention of neovascularization and suggest that anticancer effects of vialinin A could be mediated through its potent antioxidant and antiangiogenic properties.
American Psychological Association (APA)
Sonowal, Himangshu& Shukla, Kirtikar& Kota, Sumedha& Saxena, Ashish& Ramana, Kota V.. 2018. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210806
Modern Language Association (MLA)
Sonowal, Himangshu…[et al.]. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210806
American Medical Association (AMA)
Sonowal, Himangshu& Shukla, Kirtikar& Kota, Sumedha& Saxena, Ashish& Ramana, Kota V.. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210806