Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression
Joint Authors
Kwak, Young-Lan
Jun, Ji Hae
Shim, Jae-Kwang
Shin, Eun-Jung
Shin, Eunah
Park, Jin Ha
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Even after recovery from acute kidney injury, glomeruli remain vulnerable to further injury by way of interstitial fibrosis.
This study is aimed at elucidating the effects of post ischemia-reperfusion (I/R) treatment with trimetazidine on the progression to renal fibrosis as well as short- and intermediate-term aspects.
Trimetazidine 3 mg/kg or 0.9% saline was given intraperitoneally once upon reperfusion or daily thereafter for 5 d or 8 w.
Renal histologic changes and related signaling proteins were assessed.
After 24 h, post I/R treatment with trimetazidine significantly reduced serum blood urea nitrogen and creatinine levels and tubular injury accompanied with upregulation of hypoxia-inducible factor- (HIF-) 1α, vascular endothelial growth factor (VEGF), and Bcl-2 expression.
After 5 d, post I/R treatment with trimetazidine reduced renal tubular cell necrosis and apoptosis with upregulation of HIF-1α-VEGF and tissue inhibitors of metalloproteinase activities, attenuation of matrix metalloproteinase activities, and alteration of the ratio of Bax to Bcl-2 levels.
After 8 w, however, post I/R treatment with trimetazidine did not modify the progression of renal fibrosis.
In conclusion, post I/R treatment with trimetazidine allows ischemic kidneys to regain renal function and structure more rapidly compared to nontreated kidneys, but not enough to resolute renal fibrosis in long-term aspect.
American Psychological Association (APA)
Park, Jin Ha& Jun, Ji Hae& Shim, Jae-Kwang& Shin, Eun-Jung& Shin, Eunah& Kwak, Young-Lan. 2018. Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210817
Modern Language Association (MLA)
Park, Jin Ha…[et al.]. Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210817
American Medical Association (AMA)
Park, Jin Ha& Jun, Ji Hae& Shim, Jae-Kwang& Shin, Eun-Jung& Shin, Eunah& Kwak, Young-Lan. Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210817