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Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology
Joint Authors
Rengo, Giuseppe
Paolocci, Nazareno
Bencivenga, Leonardo
Ferrara, Nicola
Cannavo, Alessandro
Liccardo, Daniela
Elia, Andrea
Marzano, Federica
Gambino, Giuseppina
D’Amico, Maria Loreta
Perna, Claudia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mineralocorticoid hormone aldosterone (Aldo) has been intensively studied for its ability to influence both the physiology and pathophysiology of the cardiovascular system.
Indeed, although research on Aldo actions for decades has mainly focused on its effects in the kidney, several lines of evidence have now demonstrated that this hormone exerts disparate extrarenal adverse effects, especially in the circulatory system.
Accordingly, in the last lusters, a number of studies in preclinical models (in vitro and in vivo) and in humans have established that Aldo, following the interaction with its receptor—the mineralocorticoid receptor (MR)—is able to activate specific intracellular genomic and nongenomic pathways, thus regulating the homeostasis of the cardiovascular system.
Importantly, through this mechanism of action, this hormone becomes a crucial regulator of the function and growth of different types of cells, including fibroblasts, cardiomyocytes, and vascular cells.
For this main reason, it is plausible that when Aldo is present at high levels in the blood, it profoundly modifies the physiology of these cells, therefore being at the foundation of several cardiovascular disorders, such as heart failure (HF).
On these grounds, in this review, we will provide an updated account on the current knowledge concerning Aldo activity in the cardiovascular system and the most recent preclinical studies and clinical trials designed to test better approaches able to counter the hyperactivity of the Aldo/MR signaling pathway in the setting of cardiovascular diseases.
American Psychological Association (APA)
Cannavo, Alessandro& Bencivenga, Leonardo& Liccardo, Daniela& Elia, Andrea& Marzano, Federica& Gambino, Giuseppina…[et al.]. 2018. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210829
Modern Language Association (MLA)
Cannavo, Alessandro…[et al.]. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210829
American Medical Association (AMA)
Cannavo, Alessandro& Bencivenga, Leonardo& Liccardo, Daniela& Elia, Andrea& Marzano, Federica& Gambino, Giuseppina…[et al.]. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210829