Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders
Joint Authors
Choi, Dong-Kug
Karthivashan, Govindarajan
Jakaria, Md.
Cho, Duk-Yeon
Ezazul Haque, Md.
Kim, In-Su
Ganesan, Palanivel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections.
In addition, it might be a potential neuropharmacological agent because it exhibits versatile potential for attenuating neurological impairments.
It features greater beneficial effects in toxin-induced neuroinflammation and neurotoxicity.
In various models of neurological disorders, it demonstrates emergent functions, including safeguarding various neurodegenerative diseases and other neurological diseases, such as stroke, schizophrenia, and epilepsy.
TQ also has potential effects in trauma mediating and chemical-, radiation-, and drug-induced central nervous system injuries.
Considering the pharmacokinetic limitations, research has concentrated on different TQ novel formulations and delivery systems.
Here, we visualize the neuropharmacological potential, challenges, and delivery prospects of TQ, specifically focusing on neurological disorders along with its chemistry, pharmacokinetics, and toxicity.
American Psychological Association (APA)
Jakaria, Md.& Cho, Duk-Yeon& Ezazul Haque, Md.& Karthivashan, Govindarajan& Kim, In-Su& Ganesan, Palanivel…[et al.]. 2018. Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210831
Modern Language Association (MLA)
Jakaria, Md.…[et al.]. Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1210831
American Medical Association (AMA)
Jakaria, Md.& Cho, Duk-Yeon& Ezazul Haque, Md.& Karthivashan, Govindarajan& Kim, In-Su& Ganesan, Palanivel…[et al.]. Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210831