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Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21
Joint Authors
Lei, Jianjun
Ma, Qingyong
Zhou, Cancan
Shan, Tao
Qian, Weikun
Li, Jie
Ma, Jiguang
Yan, Bin
Cheng, Liang
Jiang, Zhengdong
Chen, Ke
Sun, Liankang
Cao, Junyu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Activation of pancreatic stellate cells (PSCs) initiates pancreatic fibrosis in chronic pancreatitis and furnishes a niche that enhances the malignancy of pancreatic cancer cells (PCCs) in pancreatic ductal adenocarcinoma (PDAC).
Resveratrol (RSV), a natural polyphenol, exhibits potent antioxidant and anticancer effects.
However, whether and how RSV influences the biological properties of activated PSCs and the effects of these changes on tumor remain unknown.
In the present study, we found that RSV impeded hydrogen peroxide-driven reactive oxygen species- (ROS-) induced activation, invasion, migration, and glycolysis of PSCs.
In addition, miR-21 expression in activated PSCs was downregulated after RSV treatment, whereas the PTEN protein level increased.
miR-21 silencing attenuated ROS-induced activation, invasion, migration, and glycolysis of PSCs, whereas the overexpression of miR-21 rescued the responses of PSCs treated with RSV.
Moreover, RSV or N-acetyl-L-cysteine (NAC) administration or miR-21 knockdown in PSCs reduced the invasion and migration of PCCs in coculture, and the effects of RSV were partly reversed by miR-21 upregulation.
Collectively, RSV inhibits PCC invasion and migration through suppression of ROS/miR-21-mediated activation and glycolysis in PSCs.
Therefore, targeting miR-21-mediated glycolysis by RSV in tumor stroma may serve as a new strategy for clinical PDAC prevention or treatment.
American Psychological Association (APA)
Yan, Bin& Cheng, Liang& Jiang, Zhengdong& Chen, Ke& Zhou, Cancan& Sun, Liankang…[et al.]. 2018. Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210857
Modern Language Association (MLA)
Yan, Bin…[et al.]. Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210857
American Medical Association (AMA)
Yan, Bin& Cheng, Liang& Jiang, Zhengdong& Chen, Ke& Zhou, Cancan& Sun, Liankang…[et al.]. Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210857