Bach1: Function, Regulation, and Involvement in Disease
Joint Authors
Meng, Dan
Zhang, Xinyue
Guo, Jieyu
Wei, Xiangxiang
Niu, Cong
Jia, Mengping
Li, Qinhan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes.
It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis.
This review summarizes how Bach1 controls these and other cellular and physiological and pathological processes.
Bach1 expression and function differ between different cell types.
Thus, therapies designed to manipulate Bach1 expression will need to be tightly controlled and tailored for each specific disease state or cell type.
American Psychological Association (APA)
Zhang, Xinyue& Guo, Jieyu& Wei, Xiangxiang& Niu, Cong& Jia, Mengping& Li, Qinhan…[et al.]. 2018. Bach1: Function, Regulation, and Involvement in Disease. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210867
Modern Language Association (MLA)
Zhang, Xinyue…[et al.]. Bach1: Function, Regulation, and Involvement in Disease. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210867
American Medical Association (AMA)
Zhang, Xinyue& Guo, Jieyu& Wei, Xiangxiang& Niu, Cong& Jia, Mengping& Li, Qinhan…[et al.]. Bach1: Function, Regulation, and Involvement in Disease. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210867