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Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42
Joint Authors
Chávez, Raúl
Guevara, J.
Treviño, Samuel
Díaz, Alfonso
Muñoz-Arenas, Guadalupe
Lopez-Lopez, Gustavo
Venegas, Berenice
Escobedo, Claudia
Moran, Carolina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS).
It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex.
However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of Aβ1–42 into the hippocampus of rats as a model of Alzheimer disease (AD).
The induction of MS in rats produces a deterioration in NORt; however, rats with MS injected with Aβ1–42 show a major deterioration in the cognitive process.
This event could be explained by the increment in the oxidative stress in both cases studied (MS and Aβ1–42): together, the hippocampus and temporal cortex produce an enhancer effect.
In the same way, we observed an increment in interleukin-1β, TNF-α, and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and Aβ1–42.
We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD.
We propose that metabolic theory is important to explain the apparition of cognitive diseases.
American Psychological Association (APA)
Díaz, Alfonso& Escobedo, Claudia& Treviño, Samuel& Chávez, Raúl& Lopez-Lopez, Gustavo& Moran, Carolina…[et al.]. 2018. Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210868
Modern Language Association (MLA)
Díaz, Alfonso…[et al.]. Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1210868
American Medical Association (AMA)
Díaz, Alfonso& Escobedo, Claudia& Treviño, Samuel& Chávez, Raúl& Lopez-Lopez, Gustavo& Moran, Carolina…[et al.]. Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210868