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Evaluation of Oxidative Stress in Cardiomyocytes during the Aging Process in Rats Treated with Resveratrol
Joint Authors
Brambila, Eduardo
Aguilar-Alonso, Patricia
Navarro-Cruz, Addí Rhode
Lazcano-Hernández, Martin Alvaro
Vera-López, Obdulia
Segura-Badilla, O.
Avalos-López, R.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The substantial increase in the number of elderly people in our societies represents a challenge for biology and medicine.
The societies of the industrialized countries are subject to a progressive aging process that translates into an increase in the cardiovascular risk of the population.
In the present work, the activity of catalase and superoxide dismutase was evaluated, as well as markers of oxidative stress (concentration of nitric oxide and total lipoperoxidation in its main components: malondialdehyde and 4-hydroxyalkene) in cardiomyocytes during the aging process in rats treated with resveratrol.
Rats were divided into 4 groups according to the following categories: control (without treatment), negative control group (administered with physiological solution with 10% ethanol), positive control group (administered with vitamin E, 2 mg/kg/day), and group administered with resveratrol (10 mg/kg/day); these groups in turn were divided into 2, 4, 6, and 8 months of treatment.
The analysis of nitric oxide showed a decreased level in the cardiac tissue in the groups treated with resveratrol; the same occurs when total lipoperoxidation is analyzed.
The enzymatic activity studied (catalase and superoxide dismutase) did not present significant changes with respect to the controls.
It is concluded that the cardioprotective effect of resveratrol is due to the antioxidant effect and other antiaging effects and not to the activation of the enzymes catalase and superoxide dismutase.
American Psychological Association (APA)
Aguilar-Alonso, Patricia& Vera-López, Obdulia& Brambila, Eduardo& Segura-Badilla, O.& Avalos-López, R.& Lazcano-Hernández, Martin Alvaro…[et al.]. 2018. Evaluation of Oxidative Stress in Cardiomyocytes during the Aging Process in Rats Treated with Resveratrol. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210871
Modern Language Association (MLA)
Aguilar-Alonso, Patricia…[et al.]. Evaluation of Oxidative Stress in Cardiomyocytes during the Aging Process in Rats Treated with Resveratrol. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210871
American Medical Association (AMA)
Aguilar-Alonso, Patricia& Vera-López, Obdulia& Brambila, Eduardo& Segura-Badilla, O.& Avalos-López, R.& Lazcano-Hernández, Martin Alvaro…[et al.]. Evaluation of Oxidative Stress in Cardiomyocytes during the Aging Process in Rats Treated with Resveratrol. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210871