Intracellular and Intercellular Signalling Mechanisms following DNA Damage Are Modulated By PINK1
Joint Authors
Temelie, Mihaela
Savu, Diana Iulia
Moisoi, Nicoleta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Impaired mitochondrial function and accumulation of DNA damage have been recognized as hallmarks of age-related diseases.
Mitochondrial dysfunction initiates protective signalling mechanisms coordinated at nuclear level particularly by modulating transcription of stress signalling factors.
In turn, cellular response to DNA lesions comprises a series of interconnected complex protective pathways, which require the energetic and metabolic support of the mitochondria.
These are involved in intracellular as well as in extracellular signalling of damage.
Here, we have initiated a study that addresses how mitochondria-nucleus communication may occur in conditions of combined mitochondrial dysfunction and genotoxic stress and what are the consequences of this interaction on the cell system.
In this work, we used cells deficient for PINK1, a mitochondrial kinase involved in mitochondrial quality control whose loss of function leads to the accumulation of dysfunctional mitochondria, challenged with inducers of DNA damage, namely, ionizing radiation and the radiomimetic bleomycin.
Combined stress at the level of mitochondria and the nucleus impairs both mitochondrial and nuclear functions.
Our findings revealed exacerbated sensibility to genotoxic stress in PINK1-deficient cells.
The same cells showed an impaired induction of bystander phenomena following stress insults.
However, these cells responded adaptively when a challenge dose was applied subsequently to a low-dose treatment to the cells.
The data demonstrates that PINK1 modulates intracellular and intercellular signalling pathways, particularly adaptive responses and transmission of bystander signalling, two facets of the cell-protective mechanisms against detrimental agents.
American Psychological Association (APA)
Temelie, Mihaela& Savu, Diana Iulia& Moisoi, Nicoleta. 2018. Intracellular and Intercellular Signalling Mechanisms following DNA Damage Are Modulated By PINK1. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210872
Modern Language Association (MLA)
Temelie, Mihaela…[et al.]. Intracellular and Intercellular Signalling Mechanisms following DNA Damage Are Modulated By PINK1. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210872
American Medical Association (AMA)
Temelie, Mihaela& Savu, Diana Iulia& Moisoi, Nicoleta. Intracellular and Intercellular Signalling Mechanisms following DNA Damage Are Modulated By PINK1. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210872