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Implication of the PI3KAktmTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging
Joint Authors
Alvarez-Mon, Melchor
Ortega, Miguel A
Asúnsolo, Ángel
Romero, Beatriz
Sainz, Felipe
Buján, Julia
García-Honduvilla, Natalio
Álavrez-Rocha, María J.
Leal, Javier
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Chronic venous insufficiency (CVI) is a multifactorial disease, commonly caused by valvular incompetence (clinically diagnosed by venous reflux) and venous hypertension.
The incidence of these factors clearly increases with patient age, and aging is one of the risk factors involved.
The activity of the PI3K/Akt/mTOR pathway is considered fundamental in vascular pathologies, and understanding its involvement would help in the development of possible therapeutic targets.
This is an observational, analytical, and prospective cohort study that reviewed 110 patients with CVI scheduled to undergo stratified saphenectomy.
They were distributed according to the presence (R=81) or absence (NR=29) of valvular incompetence (venous reflux) diagnosed clinically.
Each of the groups was further divided according to age, with a cutoff point of 50 years (NR<50=13, NR≥50=16, R<50=32, and R≥50=49).
The involvement of the PI3K/Akt/mTOR pathway, as well as that of HIF-1α and HIF-2α and of CD4+, CD8+, and CD19+ cells and mastocytes, was assessed.
Saphenous vein tissue samples obtained during surgery were processed for RT-qPCR and immunohistochemistry.
Patients with venous reflux showed a significant increase in mRNA and protein expression levels for PI3K/mTOR and HIF-1α/HIF-2α.
The number of mast cells was significantly elevated in the R group.
In distribution by age, PI3K/Akt/mTOR and HIF-1α were significantly higher in R<50 patients.
Furthermore, these patients had a significant increase in the number of CD4+, CD8+, and CD19+ cells and mastocytes in the saphenous vein wall.
These findings provide a basis for the possible existence of changes in PI3K/Akt/mTOR pathway expression in young patients, with potential accelerated asynchronous aging that is enhanced by CVI.
American Psychological Association (APA)
Ortega, Miguel A& Asúnsolo, Ángel& Leal, Javier& Romero, Beatriz& Álavrez-Rocha, María J.& Sainz, Felipe…[et al.]. 2018. Implication of the PI3KAktmTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210881
Modern Language Association (MLA)
Ortega, Miguel A…[et al.]. Implication of the PI3KAktmTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1210881
American Medical Association (AMA)
Ortega, Miguel A& Asúnsolo, Ángel& Leal, Javier& Romero, Beatriz& Álavrez-Rocha, María J.& Sainz, Felipe…[et al.]. Implication of the PI3KAktmTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210881