Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends
Joint Authors
Marino, Angela
Donnini, Sandra
Tamma, Grazia
Valenti, Giovanna
Grossini, Elena
Marinelli, Raul A.
Calamita, Giuseppe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes.
While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases.
Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis.
Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact.
This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology.
The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.
American Psychological Association (APA)
Tamma, Grazia& Valenti, Giovanna& Grossini, Elena& Donnini, Sandra& Marino, Angela& Marinelli, Raul A.…[et al.]. 2018. Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210882
Modern Language Association (MLA)
Tamma, Grazia…[et al.]. Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1210882
American Medical Association (AMA)
Tamma, Grazia& Valenti, Giovanna& Grossini, Elena& Donnini, Sandra& Marino, Angela& Marinelli, Raul A.…[et al.]. Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210882