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Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.
Joint Authors
Lin, Yanfei
Sun, Yujuan
Xiang, Lan
Qi, Jianhua
Pan, Yanjun
Farooq, Umer
Cao, Xueli
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Methanol extracts of Momordica charantia L.
fruits are extensively studied for their antiaging activities.
A new cucurbitane-type triterpenoid (1) and nine other known compounds (2–10) were isolated, and their structures were determined according to their spectroscopic characteristics and chemical derivatization.
Biological evaluation was performed on a K6001 yeast bioassay system.
The results indicated that all the compounds extended the replicative lifespan of K6001 yeast significantly.
Compound 9 was used to investigate the mechanism involved in the increasing of the lifespan.
The results indicated that this compound significantly increases the survival rate of yeast under oxidative stress and decreases ROS level.
Further study on gene expression analysis showed that compound 9 could reduce the levels of UTH1 and SKN7 and increase SOD1 and SOD2 gene expression.
In addition, it could not extend the lifespan of the yeast mutants of Uth1, Skn7, Sod1, and Sod2.
These results demonstrate that compound 9 exerts antiaging effects via antioxidative stress and regulation of UTH1, SKN7, SOD1, and SOD2 yeast gene expression.
American Psychological Association (APA)
Cao, Xueli& Sun, Yujuan& Lin, Yanfei& Pan, Yanjun& Farooq, Umer& Xiang, Lan…[et al.]. 2018. Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210884
Modern Language Association (MLA)
Cao, Xueli…[et al.]. Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210884
American Medical Association (AMA)
Cao, Xueli& Sun, Yujuan& Lin, Yanfei& Pan, Yanjun& Farooq, Umer& Xiang, Lan…[et al.]. Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210884