Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity
Joint Authors
Danesi, Francesca
Valli, Veronica
Heilmann, Katharina
Bordoni, Alessandra
Gerhäuser, Clarissa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Obesity is characterized by excess body fat accumulation due to an increase in the size and number of differentiated mature adipocytes.
Adipocyte differentiation is regulated by genetic and environmental factors, and its inhibition could represent a strategy for obesity prevention and treatment.
The current study was designed with two aims: (i) to evaluate the changes in the expression of adipogenic markers (C/EBPα, PPARγ variant 1 and variant 2, and GLUT4) in 3T3-L1 murine preadipocytes at four stages of the differentiation process and (ii) to compare the effectiveness of sulforaphane, genistein, and docosahexaenoic acid in reducing lipid accumulation and modulating C/EBPα, PPARγ1, PPARγ2, and GLUT4 mRNA expression in mature adipocytes.
All bioactive compounds were shown to suppress adipocyte differentiation, although with different effectiveness.
These results set the stage for further studies considering natural food constituents as important agents in preventing or treating obesity.
American Psychological Association (APA)
Valli, Veronica& Heilmann, Katharina& Danesi, Francesca& Bordoni, Alessandra& Gerhäuser, Clarissa. 2018. Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210889
Modern Language Association (MLA)
Valli, Veronica…[et al.]. Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210889
American Medical Association (AMA)
Valli, Veronica& Heilmann, Katharina& Danesi, Francesca& Bordoni, Alessandra& Gerhäuser, Clarissa. Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210889