In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones
Joint Authors
Valderrama, Jaime
Rios, David
Buc Calderon, Pedro
Benites, Julio
Toledo, Héctor
Salas, Felipe
Guerrero, Angélica
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Infection by Helicobacter pylori increases 10 times the risk of developing gastric cancer.
Juglone, a natural occurring 1,4-naphthoquinone, prevents H.
pylori growth by interfering with some of its critical metabolic pathways.
Here, we report the design, synthesis, and in vitro evaluation of a series of juglone derivatives, namely, 2/3-phenylaminojuglones, as potential H.
pylori growth inhibitors.
Results show that 5 out of 12 phenylaminojuglones (at 1.5 μg/mL) were 1.5–2.2-fold more active than juglone.
Interestingly, most of the phenylaminojuglones (10 out of 12) were 1.1–2.8 fold more active than metronidazole, a known H.
pylori growth inhibitor.
The most active compound, namely, 2-((3,4,5-trimethoxyphenyl)amino)-5-hydroxynaphthalene-1,4-dione 7, showed significant higher halo of growth inhibitions (HGI = 32.25 mm) to that of juglone and metronidazole (HGI = 14.50 and 11.67 mm).
Structural activity relationships of the series suggest that the nature and location of the nitrogen substituents in the juglone scaffold, likely due in part to their redox potential, may influence the antibacterial activity of the series.
American Psychological Association (APA)
Benites, Julio& Toledo, Héctor& Salas, Felipe& Guerrero, Angélica& Rios, David& Valderrama, Jaime…[et al.]. 2018. In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210891
Modern Language Association (MLA)
Benites, Julio…[et al.]. In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210891
American Medical Association (AMA)
Benites, Julio& Toledo, Héctor& Salas, Felipe& Guerrero, Angélica& Rios, David& Valderrama, Jaime…[et al.]. In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210891