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Nonylphenol and Octylphenol Differently Affect Cell Redox Balance by Modulating the Nitric Oxide Signaling
Joint Authors
Magnifico, Maria Chiara
Xhani, Marla
Popov, Milica
Sarti, Paolo
Arese, Marzia
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nonylphenol (NP) and octylphenol (OP) are pervasive environmental contaminants belonging to the broader class of compounds known as alkylphenols, with potential human toxic effects.
Classified as “xenoestrogens,” NP and OP are able to interfere with the cell endocrine physiology via a direct interaction with the estrogen receptors.
Here, using HepG2 cells in culture, the changes of the cell redox balance and mitochondrial activity induced by OP and NP have been investigated at μM concentrations, largely below those provoking acute toxicity, as those typical of environmental contaminants.
Following 24 h cell exposure to both OP and NP, ROS production appeared significantly increased (p≤0.01), together with the production of higher NO oxides (p=0.003) and peroxynitrated protein-derivatives (NP versus CTR, p=0.003).
The mitochondrial proton electrochemical potential gradient instead was decreased (p≤0.05), as the oxygen consumption by complex IV, particularly following incubation with NP (NP versus CTR, p=0.017).
Consistently, the RT-PCR and Western blot analyses proved that the OP and NP can modulate to a different extent the expression of the inducible NOS (NP versus CTR, p≤0.01) and the endothelial NOS (OP versus CTR, p≤0.05), with a significant variation of the coupling efficiency of the latter (NP versus CTR, p≤0.05), a finding that may provide a novel clue to understand the specific xenoestrogenic properties of OP and NP.
American Psychological Association (APA)
Magnifico, Maria Chiara& Xhani, Marla& Popov, Milica& Saso, Luciano& Sarti, Paolo& Arese, Marzia. 2018. Nonylphenol and Octylphenol Differently Affect Cell Redox Balance by Modulating the Nitric Oxide Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210897
Modern Language Association (MLA)
Magnifico, Maria Chiara…[et al.]. Nonylphenol and Octylphenol Differently Affect Cell Redox Balance by Modulating the Nitric Oxide Signaling. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1210897
American Medical Association (AMA)
Magnifico, Maria Chiara& Xhani, Marla& Popov, Milica& Saso, Luciano& Sarti, Paolo& Arese, Marzia. Nonylphenol and Octylphenol Differently Affect Cell Redox Balance by Modulating the Nitric Oxide Signaling. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210897