R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography
Joint Authors
Gussoni, Maristella
Montorsi, Michela
Moretti, Sarah
Mrakic-Sposta, Simona
Greco, Fulvia
Maderna, Luca
Gregorini, Francesca
Cova, Emanuela
Vezzoli, Alessandra
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objectives.
Diabetic neuropathy is the most common complication of diabetes.
The idea of alterations in energy metabolism in diabetes is emerging.
The biogenic antioxidant R(+)-thioctic acid has been successfully used in the treatment of diabetic polyneuropathic (DPN) patients.
Methods.
The effects of R(+)-thioctic acid (1 tablet, 1.6 g) administration were evaluated in 12 DPN patients at baseline and at 15, 30, 60, and 120 administration days throughout the assessment of oxidative stress (OxS); ROS production rate by electron paramagnetic resonance (EPR) technique; and oxidative damage biomarkers (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC)), electroneurography (ENG) and visual analogue scale.
Results.
Supplementation induced significant changes (p<0.05) at 30 and 60 days.
ROS production rate up to −16%; TBARS (−31%), PC (−38%), and TAC up to +48%.
Motor nerve conduction velocity in SPE and ulnar nerves (+22% and +16%) and sensor conduction velocity in sural and median nerves (+22% and +5%).
Patients reported a general wellness sensation improvement (+35%) at 30 days: lower limb pain sensation (−40%) and upper limbs (−23%).
Conclusion.
The results strongly indicate that an increased antioxidant capacity plays an important role in OxS, nerve conduction velocity, pain, and general wellness improvement.
Nevertheless, the effects of the antioxidant compound were found positive up to 60 days.
Then, a hormesis effect was observed.
Novelty of the research would be a challenge for investigators to carefully address issues, including dose range factors, appropriate administration time, and targeting population to counteract possible “boomerang effects.” The great number of monitored parameters would firmly stress these conclusions.
American Psychological Association (APA)
Mrakic-Sposta, Simona& Vezzoli, Alessandra& Maderna, Luca& Gregorini, Francesca& Montorsi, Michela& Moretti, Sarah…[et al.]. 2018. R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210912
Modern Language Association (MLA)
Mrakic-Sposta, Simona…[et al.]. R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210912
American Medical Association (AMA)
Mrakic-Sposta, Simona& Vezzoli, Alessandra& Maderna, Luca& Gregorini, Francesca& Montorsi, Michela& Moretti, Sarah…[et al.]. R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210912