Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment
Joint Authors
Corrente, José Eduardo
dos Santos, Klinsmann Carolo
Nakamune, Ana Cláudia de Melo Stevanato
Gonçalves, Bianca Mariani
Ferraz, Ana Paula C. R.
Cury, Sarah Santiloni
de Araújo Machado, Luiz Henrique
Carvalho, Robson Francisco
Fabro, Alexandre Todorovic
Freire, Paula Paccielli
Corrêa, Camila Renata
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated.
The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE.
Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg−1/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d.
The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue.
The apparent benefits of YLE seem to be mediated by ameliorating dysmetabolism and oxidative stress in pancreatic and cardiac tissues.
American Psychological Association (APA)
dos Santos, Klinsmann Carolo& Cury, Sarah Santiloni& Ferraz, Ana Paula C. R.& Corrente, José Eduardo& Gonçalves, Bianca Mariani& de Araújo Machado, Luiz Henrique…[et al.]. 2018. Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210924
Modern Language Association (MLA)
dos Santos, Klinsmann Carolo…[et al.]. Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210924
American Medical Association (AMA)
dos Santos, Klinsmann Carolo& Cury, Sarah Santiloni& Ferraz, Ana Paula C. R.& Corrente, José Eduardo& Gonçalves, Bianca Mariani& de Araújo Machado, Luiz Henrique…[et al.]. Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210924