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Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System
Joint Authors
Kim, Min-Sik
Jung, Junyang
Shefa, Ulfuara
Jeong, Na Young
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Hydrogen sulfide (H2S), a toxic gaseous molecule, plays a physiological role in regulating homeostasis and cell signaling.
H2S is produced from cysteine by enzymes, such as cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST).
These enzymes regulate the overall production of H2S in the body.
H2S has a cell-signaling function in the CNS and plays important roles in combating oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body.
H2S is crucial for maintaining balanced amounts of antioxidants to protect the body from oxidative stress, and appropriate amounts of H2S are required to protect the CNS in particular.
The body regulates CBS, 3MST, and CSE levels in the CNS, and higher or lower levels of these enzymes cause various neurodegenerative diseases.
This review discusses how H2S protects the CNS by acting as an antioxidant that reduces excessive amounts of ROS and RNS.
Additionally, H2S regulates cell signaling to combat neuroinflammation and protect against central neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS).
American Psychological Association (APA)
Shefa, Ulfuara& Kim, Min-Sik& Jeong, Na Young& Jung, Junyang. 2018. Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210939
Modern Language Association (MLA)
Shefa, Ulfuara…[et al.]. Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1210939
American Medical Association (AMA)
Shefa, Ulfuara& Kim, Min-Sik& Jeong, Na Young& Jung, Junyang. Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210939