Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains
Joint Authors
Zadrag-Tecza, Renata
Kwolek-Mirek, Magdalena
Alabrudzińska, Małgorzata
Skoneczna, Adrianna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The total lifespan of the yeast Saccharomyces cerevisiae may be divided into two phases: the reproductive phase, during which the cell undergoes mitosis cycles to produce successive buds, and the postreproductive phase, which extends from the last division to cell death.
These phases may be regulated by a common mechanism or by distinct ones.
In this paper, we proposed a more comprehensive approach to reveal the mechanisms that regulate both reproductive potential and total lifespan in cell size context.
Our study was based on yeast cells, whose size was determined by increased genome copy number, ranging from haploid to tetraploid.
Such experiments enabled us to test the hypertrophy hypothesis, which postulates that excessive size achieved by the cell—the hypertrophy state—is the reason preventing the cell from further proliferation.
This hypothesis defines the reproductive potential value as the difference between the maximal size that a cell can reach and the threshold value, which allows a cell to undergo its first cell cycle and the rate of the cell size to increase per generation.
Here, we showed that cell size has an important impact on not only the reproductive potential but also the total lifespan of this cell.
Moreover, the maximal cell size value, which limits its reproduction capacity, can be regulated by different factors and differs depending on the strain ploidy.
The achievement of excessive size by the cell (hypertrophic state) may lead to two distinct phenomena: the cessation of reproduction without “mother” cell death and the cessation of reproduction with cell death by bursting, which has not been shown before.
American Psychological Association (APA)
Zadrag-Tecza, Renata& Kwolek-Mirek, Magdalena& Alabrudzińska, Małgorzata& Skoneczna, Adrianna. 2018. Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210943
Modern Language Association (MLA)
Zadrag-Tecza, Renata…[et al.]. Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1210943
American Medical Association (AMA)
Zadrag-Tecza, Renata& Kwolek-Mirek, Magdalena& Alabrudzińska, Małgorzata& Skoneczna, Adrianna. Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210943