Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells
Joint Authors
Zheng, Qiusheng
Chen, Xiaoyu
Wang, Dan
Li, Kai
Wang, Yunchao
Wang, Jianning
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer.
Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine.
Although IBC demonstrates potent anticancer efficacy in numerous types of human cancer cells, the cellular targets of IBC have not been fully defined.
In our study, we found that IBC may induce reactive oxygen species- (ROS-) mediated apoptosis via interaction with a selenocysteine (Sec) containing the antioxidant enzyme thioredoxin reductase 1 (TrxR1), and induce lethal endoplasmic reticulum (ER) stress by inhibiting TrxR1 activity and increasing ROS levels in human prostate cancer PC-3 cells.
Furthermore, we also observed that knocking down TrxR1 would sensitized cancer cells to IBC treatment.
Our study provides evidence for the anticancer mechanism of IBC with TrxR1 as a potential target.
American Psychological Association (APA)
Li, Kai& Zheng, Qiusheng& Chen, Xiaoyu& Wang, Yunchao& Wang, Dan& Wang, Jianning. 2018. Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210948
Modern Language Association (MLA)
Li, Kai…[et al.]. Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1210948
American Medical Association (AMA)
Li, Kai& Zheng, Qiusheng& Chen, Xiaoyu& Wang, Yunchao& Wang, Dan& Wang, Jianning. Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1210948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210948