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The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms
Joint Authors
Santos, Ana L.
Lindner, Ariel B.
Sinha, Sanchari
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-18
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Aging is associated with the accumulation of cellular damage over the course of a lifetime.
This process is promoted in large part by reactive oxygen species (ROS) generated via cellular metabolic and respiratory pathways.
Pharmacological, nonpharmacological, and genetic interventions have been used to target cellular and mitochondrial networks in an effort to decipher aging and age-related disorders.
While ROS historically have been viewed as a detrimental byproduct of normal metabolism and associated with several pathologies, recent research has revealed a more complex and beneficial role of ROS in regulating metabolism, development, and lifespan.
In this review, we summarize the recent advances in ROS research, focusing on both the beneficial and harmful roles of ROS, many of which are conserved across species from bacteria to humans, in various aspects of cellular physiology.
These studies provide a new context for our understanding of the parts ROS play in health and disease.
Moreover, we highlight the utility of bacterial models to elucidate the molecular pathways by which ROS mediate aging and aging-related diseases.
American Psychological Association (APA)
Santos, Ana L.& Sinha, Sanchari& Lindner, Ariel B.. 2018. The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1210955
Modern Language Association (MLA)
Santos, Ana L.…[et al.]. The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1210955
American Medical Association (AMA)
Santos, Ana L.& Sinha, Sanchari& Lindner, Ariel B.. The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1210955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210955