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Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown
Joint Authors
Thao, Dang Thi Phuong
Huynh, Man Anh
Vuu, My Dung
Nguyen, Thi Thanh
Tran, Linh Thuoc
Yamaguchi, Masamitsu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The relationship between oxidative stress and neurodegenerative diseases has been extensively examined, and antioxidants are considered to be a promising approach for decelerating disease progression.
Parkinson’s disease (PD) is a common neurodegenerative disorder and affects 1% of the population over 60 years of age.
A complex combination of genetic and environmental factors contributes to the pathogenesis of PD.
However, since the onset mechanisms of PD have not yet been elucidated in detail, difficulties are associated with developing effective treatments.
Curcumin has been reported to have neuroprotective properties in PD models induced by neurotoxins or genetic factors such as α-synuclein, PINK1, DJ-1, and LRRK2.
In the present study, we investigated the effects of curcumin in a novel Drosophila model of PD with knockdown of dUCH, a homolog of human UCH-L1.
We found that dopaminergic neuron-specific knockdown of dUCH caused impaired movement and the loss of dopaminergic neurons.
Furthermore, the knockdown of dUCH induced oxidative stress while curcumin decreased the ROS level induced by this knockdown.
In addition, dUCH knockdown flies treated with curcumin had improved locomotive abilities and less severe neurodegeneration.
Taken together, with studies on other PD models, these results strongly suggest that treatments with curcumin are an appropriate therapy for PD related to oxidative stress.
American Psychological Association (APA)
Nguyen, Thi Thanh& Vuu, My Dung& Huynh, Man Anh& Yamaguchi, Masamitsu& Tran, Linh Thuoc& Thao, Dang Thi Phuong. 2018. Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210972
Modern Language Association (MLA)
Nguyen, Thi Thanh…[et al.]. Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210972
American Medical Association (AMA)
Nguyen, Thi Thanh& Vuu, My Dung& Huynh, Man Anh& Yamaguchi, Masamitsu& Tran, Linh Thuoc& Thao, Dang Thi Phuong. Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210972