A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma
Joint Authors
Lima, Tamires Cardoso
Turkez, Hasan
Tozlu, Ozlem Ozdemir
de Brito, Anna Emmanuela Medeiros
de Sousa, Damião Pergentino
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cancer is a major public health problem around the globe.
This disorder is affected by alterations in multiple physiological processes, and oxidative stress has been etiologically implicated in its pathogenesis.
Glioblastoma (GBM) is considered the most common and aggressive brain tumor with poor prognosis despite recent improvements in surgical, radiation, and chemotherapy-based treatment approaches.
The purpose of this study was to evaluate antitumor activity from Mentha crispa essential oil (MCEO), its major constituent rotundifolone (ROT), and a series of six analogues on the human U87MG glioblastoma cell line.
Cytotoxic effects of the compounds on the human U87MG-GBM cell line were assessed using in vitro cell viability and oxidative and molecular genetic assays.
In addition, biosafety assessment tests were performed on cultured human blood cells.
Our findings revealed that MCEO, 1,2-perillaldehyde epoxide (EPER1), and perillaldehyde (PALD) were the most cytotoxic compounds against U87MG cells, with IC50 values of 16.263, 15.087, and 14.888 μg/mL, respectively.
Further, these compounds increased the expressions of BRAF, EGFR, KRAS, NFκB1, NFκB1A, NFκB2, PIK3CA, PIK3R, PTEN, and TP53 genes at different degrees and decreased the expression of some genes such as AKT1, AKT2, FOS, and RAF1.
Finally, treatment with MCEO, EPER1, and PALD did not lead to genotoxic damage in blood cells.
Taken together, our findings reveal antiproliferative potential of MCEO, its major component ROT, and its tested analogues.
Some of these chemical analogues may be useful as prototypes for the development of novel chemotherapeutic agents for treating human brain cancer and/or other cancers due to their promising activities as well as nonmutagenic property and safety.
American Psychological Association (APA)
Turkez, Hasan& Tozlu, Ozlem Ozdemir& Lima, Tamires Cardoso& de Brito, Anna Emmanuela Medeiros& de Sousa, Damião Pergentino. 2018. A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210982
Modern Language Association (MLA)
Turkez, Hasan…[et al.]. A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210982
American Medical Association (AMA)
Turkez, Hasan& Tozlu, Ozlem Ozdemir& Lima, Tamires Cardoso& de Brito, Anna Emmanuela Medeiros& de Sousa, Damião Pergentino. A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210982