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Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage
Joint Authors
Torres-Manzo, Alejandra Paola
Franco-Colín, Margarita
Blas-Valdivia, Vanessa
Pineda-Reynoso, Marisol
Cano-Europa, Edgar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Thyroid hormones (TH) are essential for hippocampal neuronal viability in adulthood, and their deficiency causes hypothyroidism, which is related to oxidative stress events and neuronal damage.
Also, it has been hypothesized that hypothyroidism causes a glucose deprivation in the neuron.
This study is aimed at evaluating the temporal participation of the endoplasmic reticulum stress (ERE) in hippocampal neurons of adult hypothyroid rats and its association with the oxidative stress events.
Adult Wistar male rats were divided into euthyroid and hypothyroid groups.
Thyroidectomy with parathyroid gland reimplementation caused hypothyroidism at three weeks postsurgery.
Oxidative stress, redox environment, and antioxidant enzyme markers, as well as the expression of the ERE through the pathways of PERK, ATF6, and IRE1, were evaluated at the 3rd and 4th weeks postsurgery.
We found a rise in ROS and nitrite production; also, catalase increased and glutathione peroxidase diminished their activities.
These events promote an enhancement of the lipoperoxidation, as well as of γ-GT, myeloperoxidase, and caspase 3 activities.
With respect to ERE, there were ATF6, IRE1, and GADD153 overexpressions with a reduction in mitochondrial activity and GSH2/GSSG ratio.
We conclude that the endoplasmic reticulum stress might play a pivotal role in the activation of hypothyroidism-induced hippocampal cell death.
American Psychological Association (APA)
Torres-Manzo, Alejandra Paola& Franco-Colín, Margarita& Blas-Valdivia, Vanessa& Pineda-Reynoso, Marisol& Cano-Europa, Edgar. 2018. Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210984
Modern Language Association (MLA)
Torres-Manzo, Alejandra Paola…[et al.]. Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210984
American Medical Association (AMA)
Torres-Manzo, Alejandra Paola& Franco-Colín, Margarita& Blas-Valdivia, Vanessa& Pineda-Reynoso, Marisol& Cano-Europa, Edgar. Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210984