Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms
Joint Authors
Cobbaut, Mathias
Van Lint, Johan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen species (ROS) that destabilize the homeostatic redox balance.
High levels of ROS can cause damage to macromolecules including DNA, lipids, and proteins, eventually resulting in cell death.
Moderate levels of ROS however serve as signaling molecules that can drive and potentiate several cellular phenotypes.
Increased levels of ROS are associated with a number of diseases including neurological disorders and cancer.
In cancer, increased ROS levels can contribute to cancer cell survival and proliferation via the activation of several signaling pathways.
One of the downstream effectors of increased ROS is the protein kinase D (PKD) family of kinases.
In this review, we will discuss the regulation and function of this family of ROS-activated kinases and describe their unique isoform-specific features, in terms of both kinase regulation and signaling output.
American Psychological Association (APA)
Cobbaut, Mathias& Van Lint, Johan. 2018. Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210993
Modern Language Association (MLA)
Cobbaut, Mathias& Van Lint, Johan. Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210993
American Medical Association (AMA)
Cobbaut, Mathias& Van Lint, Johan. Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210993