Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague–Dawley Rats
Joint Authors
Skrzep-Poloczek, Bronisława
Stygar, Dominika
Chełmecka, Elżbieta
Sawczyn, Tomasz
Karcz, Konrad Wojciech
Poloczek, Jakub
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Pathophysiological links between inflammation, obesity, and adipokines can be used for the treatment of metabolic dysregulation.
Aims.
To examine the influence of duodenal-jejunal omega switch surgery in combination with different diet patterns on plasma concentrations of fatty acid-binding protein 4 (FABP4), C-reactive protein (CRP), leptin, and chemerin.
Methods.
After 8 weeks on a high-fat diet (HF) or control diet (CD), rats underwent surgery.
Duodenal-jejunal omega switch (DJOS) with an exclusion of one-third of intestinal length and SHAM surgery were performed.
For the next 8 weeks, 50% of DJOS/SHAM animals were kept on the same diet as before (HF/DJOS/HF, HF/SHAM/HF, CD/DJOS/CD, and CD/SHAM/CD), and 50% had a changed diet (HF/DJOS/CD, HF/SHAM/CD, CD/DJOS/HF, and CD/SHAM/HF).
FABP4, CRP, leptin, and chemerin were assessed using ELISA kits.
Results.
FABP4: significant differences between DJOS and SHAM were observed in animals maintained on CD/CD; CRP: varied between DJOS and SHAM groups maintained on HF/HF, CD/CD, and CD/HF; leptin and chemerin levels: DJOS lowered leptin and chemerin plasma levels versus SHAM, while HF/HF, CD/HF, and HF/CD significantly increased leptin and chemerin plasma levels when compared to CD/CD.
Conclusions.
The beneficial effect of DJOS surgery is stronger than proinflammatory conditions caused by an HF obesogenic diet.
American Psychological Association (APA)
Stygar, Dominika& Chełmecka, Elżbieta& Sawczyn, Tomasz& Skrzep-Poloczek, Bronisława& Poloczek, Jakub& Karcz, Konrad Wojciech. 2018. Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague–Dawley Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210995
Modern Language Association (MLA)
Stygar, Dominika…[et al.]. Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague–Dawley Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1210995
American Medical Association (AMA)
Stygar, Dominika& Chełmecka, Elżbieta& Sawczyn, Tomasz& Skrzep-Poloczek, Bronisława& Poloczek, Jakub& Karcz, Konrad Wojciech. Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague–Dawley Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210995