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Impact of Obesity and Hyperglycemia on Placental Mitochondria
Joint Authors
Mandò, Chiara
Anelli, Gaia Maria
Novielli, Chiara
Panina-Bordignon, Paola
Mazzocco, Martina Ilaria
Massari, Maddalena
Cetin, Irene
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A lipotoxic placental environment is recognized in maternal obesity, with increased inflammation and oxidative stress.
These changes might alter mitochondrial function, with excessive production of reactive oxygen species, in a vicious cycle leading to placental dysfunction and impaired pregnancy outcomes.
Here, we hypothesize that maternal pregestational body mass index (BMI) and glycemic levels can alter placental mitochondria.
We measured mitochondrial DNA (mtDNA, real-time PCR) and morphology (electron microscopy) in placentas of forty-seven singleton pregnancies at elective cesarean section.
Thirty-seven women were normoglycemic: twenty-one normal-weight women, NW, and sixteen obese women, OB/GDM(−).
Ten obese women had gestational diabetes mellitus, OB/GDM(+).
OB/GDM(−) presented higher mtDNA levels versus NW, suggesting increased mitochondrial biogenesis in the normoglycemic obese group.
These mitochondria showed similar morphology to NW.
On the contrary, in OB/GDM(+), mtDNA was not significantly increased versus NW.
Nevertheless, mitochondria showed morphological abnormalities, indicating impaired functionality.
The metabolic response of the placenta to impairment in obese pregnancies can possibly vary depending on several parameters, resulting in opposite strains acting when insulin resistance of GDM occurs in the obese environment, characterized by inflammation and oxidative stress.
Therefore, mitochondrial alterations represent a feature of obese pregnancies with changes in placental energetics that possibly can affect pregnancy outcomes.
American Psychological Association (APA)
Mandò, Chiara& Anelli, Gaia Maria& Novielli, Chiara& Panina-Bordignon, Paola& Massari, Maddalena& Mazzocco, Martina Ilaria…[et al.]. 2018. Impact of Obesity and Hyperglycemia on Placental Mitochondria. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211017
Modern Language Association (MLA)
Mandò, Chiara…[et al.]. Impact of Obesity and Hyperglycemia on Placental Mitochondria. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211017
American Medical Association (AMA)
Mandò, Chiara& Anelli, Gaia Maria& Novielli, Chiara& Panina-Bordignon, Paola& Massari, Maddalena& Mazzocco, Martina Ilaria…[et al.]. Impact of Obesity and Hyperglycemia on Placental Mitochondria. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211017