The Role of Free Radicals in Autophagy Regulation: Implications for Ageing
Joint Authors
Cuadrado, Antonio
Jirsova, Zuzana
Pajares, M.
Engedal, N.
Cahova, Monika
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Reactive oxygen and nitrogen species (ROS and RNS, resp.) have been traditionally perceived solely as detrimental, leading to oxidative damage of biological macromolecules and organelles, cellular demise, and ageing.
However, recent data suggest that ROS/RNS also plays an integral role in intracellular signalling and redox homeostasis (redoxtasis), which are necessary for the maintenance of cellular functions.
There is a complex relationship between cellular ROS/RNS content and autophagy, which represents one of the major quality control systems in the cell.
In this review, we focus on redox signalling and autophagy regulation with a special interest on ageing-associated changes.
In the last section, we describe the role of autophagy and redox signalling in the context of Alzheimer’s disease as an example of a prevalent age-related disorder.
American Psychological Association (APA)
Pajares, M.& Cuadrado, Antonio& Engedal, N.& Jirsova, Zuzana& Cahova, Monika. 2018. The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1211040
Modern Language Association (MLA)
Pajares, M.…[et al.]. The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1211040
American Medical Association (AMA)
Pajares, M.& Cuadrado, Antonio& Engedal, N.& Jirsova, Zuzana& Cahova, Monika. The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1211040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211040